ea0016p819 | Thyroid | ECE2008
Gassner Dieter
, Golla Ruth
, Stock Werner
, Sanders Jane
, Smith Bernard Rees
Hyperthyroidism in GravesÂ’ disease is due to TSH receptor (TSHR) autoantibodies (TRAb) directed against the TSH binding pocket. Detection of TRAb in clinical rou-tine is performed by 2nd gen assays using human or porcine TSHR. Such TSH bin- ding inhibition immunoglobulin (TBII) assays determine the ability of TRAb to inhi- bit the binding of labelled TSH to immobilized TSHR. TRAb are present in low con- centrations and mostly recognize conformational epitopes. The conform...